Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this information to adapt the cellular energy output such that it matches cellular energy requirements. The changes induced by SIRT1 activation are g...

All You Need Is Mentorship

I find it humbling to confess that most of the truly original ideas that have driven my research group’s agenda over four decades of time have come, not from my own brain, but instead from the minds of my trainees, both graduate students and post-docs. This on its own might explain why I, rather selfishly, have given them long leashes, allowing them to strike out on their own and craft their ow...

All You Need Is Compassion

The paper presents a new deductive rule for verifying response properties under the assumption of compassion (strong fairness) requirements. It improves on previous rules in that the premises of the new rule are all first order. We prove that the rule is sound, and present a constructive completeness proof for the case of finite-state systems. For the general case, we present a sketch of a rela...

CNN Is All You Need

CNNs have been successfully used in audio, image and text classification, analysis and generation [12,17,18], whereas the RNNs with LSTM cells [5,6] have been widely adopted for solving sequence transduction problems such as language modeling and machine translation [19,3,5]. The RNN models typically align the element positions of the input and output sequences to steps in computation time for ...

All you need is love?